RNA Details
Disease Name
cystic fibrosis
Tissue
lung
RNA Symbol
TLR2
RNA ID
RNA Type
mRNA
Alteration Pattern
promoter hypomethylation
Species
homo sapiens
Detection Methods
Dual-luciferase reporter assay; qRT-PCR; etc.
Target
NA
Pathway
NA
PubMed ID
Title
Promoter hypomethylation of Toll-like receptor-2 gene is associated with increased proinflammatoryresponse toward bacterial peptidoglycan in cystic fibrosis bronchial epithelial cells
Year
2006
Function
TLR2 expression is epigenetically up-regulated via promoter hypomethylation in CF bronchial epithelial cells and suggest that TLR2 overexpression or prolonged activation of TLR2 signaling might be critical in CF pathogenesis.